Informations sur l'entreprise

Nom de l'entreprise : SANOFI
Ville : Montpellier 34184

Détails du contrat

Type de contrat : cdi
Type de métier : Laboratory
Date de publication: 15/09/2022

A propos du recruteur

La vocation de Sanofi est d’accompagner celles et ceux confrontés à des difficultés de santé. Entreprise biopharmaceutique mondiale spécialisée dans la santé humaine, nous prévenons les maladies avec nos vaccins et proposons des traitements innovants. Nous accompagnons tant ceux qui sont atteints de maladies rares, que les millions de personnes souffrant d’une maladie chronique. Sanofi et ses plus de 100 000 collaborateurs dans 100 pays transforment l’innovation scientifique en solutions de santé partout dans le monde. Sanofi, Empowering Life, donner toute sa force à la vie. Chez Sanofi, la diversité et l’inclusion sont au cœur de notre fonctionnement et sont intégrées à nos Valeurs fondamentales. Nous sommes conscients que pour exploiter véritablement la richesse que la diversité nous apporte, nous devons faire preuve d’inclusion et créer un environnement de travail où ces différences peuvent s’épanouir et être développées pour améliorer le quotidien de nos collègues, patients et clients. Nous respectons et valorisons la diversité de nos collaborateurs, leurs parcours et leurs expériences dans un objectif d’égalité des chances pour tous.

Description du poste

Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail. Job title: Laboratory scientist in Metabolism Job location in Montpellier (France)No travel will be expected in this job description, except to attend congressJob type: Permanent ABOUT THE JOB Our Team We are seeking a laboratory scientist to join the Enzymology & Metabolism (E&M) group in Montpellier, within Biomarkers & Clinical Bioanalyses (BCB), a global department within the Translational Medicine and Early Development unit (TMED) of Sanofi. BCB is a global group that plays a critical role in the development of new drugs, contributing to bioanalytical strategy and translational support from nonclinical to clinical. The E&M group is considered as a Centre of Excellence (CoE) which provides data (in vitro and in vivo) and expertise to contribute to Drug-Drug Interaction (DDI)/metabolism assessments, to support small molecule projects in development. Main responsibilities The appointed candidate will be responsible for contribution to in vitro and in vivo metabolism assessment, in close collaboration with others department such as Pharmacokinetics Dynamics and Metabolism (PKDM) or Drug Metabolism and Pharmacokinetics (DMPK). We are looking for an expert in structure elucidation of metabolites, with basic understanding of the mechanisms of P-450 oxidations/reactive metabolites. You also need to have excellent knowledge of sample preparation of biofluids, liquid chromatography and high-resolution accurate mass spectrometry and have technical skills to operate and perform regular maintenance and elementary trouble shooting. Your major responsibilities will include planning, conducting and documenting experiments designed to investigate metabolic pathways and structural elucidation of metabolites formed from new drug candidate. Experience/knowledge in using relevant in vitro models such as hepatocytes, microsomes, supersomes would be considered as a plus. Apart from being responsible for studies appointed to him/her, he/she will also be a window person interacting with study monitors, project teams to ensure that metabolism contributions are conducted in a timely manner and to the highest quality standard. He/she will manage the scientific monitoring of the synthesis of radiolabeled small molecules, metabolites (non-labelled and radiolabeled); as well as internal standards necessary for the proper achievement of studies carried out in BCB. The candidate will also be the main point of contact for all study phases conducted under his/her responsibility and will work with outsourcing operational group and CROs to support scientifically external analyses. The individual in this position will support multiple projects and collaborate transversally with colleagues across the globe. This position requires an ability to work considering deadlines and project milestones, as well as the ability to prepare and write reports for regulatory submissions in support of clinical development. ABOUT YOU Experience The ideal candidate would be an experienced scientist (3-5 years), with experience/knowledge in Metabolism and structural identification of small molecules. Experience/knowledge in the regulatory bioanalysis landscape related to GxP knowledge, would be considered as a plus, as well as experience in electronic data management Technical skills Experience in Metabolism and structural identification of small molecules using Mass SpectrometryExperience/knowledge in using relevant in vitro models would be considered as a plusExperience in the regulatory bioanalysis landscape related to GxP knowledge, would be considered as a plus Soft skills Creative, highly motivated, and autonomous individual capable of collaborating within, and across teamsStrong verbal and written communication skills are also requiredVery good communication skills (many meetings/interactions in challenging contexts)Attention to detail and quality of workWell organized, able to work in a complex fast-changing environmentAble to influence/coach others inside and outside the direct environmentAble to work in autonomy, implementing/optimizing novel processes/workflowsTeam player with a mindset to participate to the laboratory life, enthusiastic, proactive, accurate in execution and reporting Education PhD in biochemistry, chemistry, or structural analysis of small molecules by mass spectrometryDegree in Chemistry/Biochemistry with experience relevant to drug metabolism science (MS with more than 5-year experience or BS with more than 10-year experience) Languages English thorough knowledge, both spoken and written is mandatory. The E&M group is in France, so French will be considered as a plus PURSUE PROGRESS, DISCOVER EXTRAORDINARY Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity. Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at!

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