SANOFI

Recherche & Développement

La vocation de Sanofi est d’accompagner celles et ceux confrontés à des difficultés de santé. Entreprise biopharmaceutique mondiale spécialisée dans la santé humaine, nous prévenons les maladies avec nos vaccins et proposons des traitements innovants. Nous accompagnons tant ceux qui sont atteints de maladies rares, que les millions de personnes souffrant d’une maladie chronique. Sanofi et ses plus de 100 000 collaborateurs dans 100 pays transforment l’innovation scientifique en solutions de santé partout dans le monde. Sanofi, Empowering Life, donner toute sa force à la vie. Chez Sanofi, la diversité et l’inclusion sont au cœur de notre fonctionnement et sont intégrées à nos Valeurs fondamentales. Nous sommes conscients que pour exploiter véritablement la richesse que la diversité nous apporte, nous devons faire preuve d’inclusion et créer un environnement de travail où ces différences peuvent s’épanouir et être développées pour améliorer le quotidien de nos collègues, patients et clients. Nous respectons et valorisons la diversité de nos collaborateurs, leurs parcours et leurs expériences dans un objectif d’égalité des chances pour tous.

Sanofi’s Immuno-Oncology Therapeutic Area based in Vitry-sur-Seine, France is seeking a highly qualified and motivated PhD level post-doctoral candidate with an interest in Natural Killer (NK) cell biology and cancer immunotherapy. The successful candidate will provide scientific leadership and play a pivotal role in advancing the understanding of NK cell regulatory mechanism and enable discovery of novel regulators of NK cell immune functions and anti-tumor activity. The candidate will have a unique opportunity to work and train in a multidisciplinary research environment and will work closely with different scientists in Immuno-Oncology, Precision Oncology and Translational Sciences. The candidate will also assume responsibility to complete leading edge research for presentation in scientific meetings and publication. Key Tasks & Responsibilities: Lead research efforts in Sanofi’s Immuno-Oncology Therapeutic Area to understand NK cell regulatory receptors in cancer.Establish an in vitro screening to discover and characterize key regulatory receptor of NK cell immune functions and anti-tumor activity.Implement multiple state-of-the-art techniques in molecular and cellular biology to increase NK cell cytotoxicity against tumor cell lines.Maintain a working knowledge of current experimental techniques and literature in the field of NK cell biology and NK cell therapies.Analyze, interpret, and present experimental results at lab meetings and share scientific results with our multi-disciplinary research group.Publish/present findings in peer-reviewed journals/scientific conferences.Work well with colleagues in a matrixed, fast-paced pharmaceutical research environment.Maintain accurate records of experiments and analyses.Maintain lucid and effective communication with manager and other colleagues Key Tasks & Responsibilities: Lead research efforts in Sanofi’s Immuno-Oncology Therapeutic Area to understand NK cell regulatory receptors in cancer.Establish an in vitro screening to discover and characterize key regulatory receptor of NK cell immune functions and anti-tumor activity.Implement multiple state-of-the-art techniques in molecular and cellular biology to increase NK cell cytotoxicity against tumor cell lines.Maintain a working knowledge of current experimental techniques and literature in the field of NK cell biology and NK cell therapies.Analyze, interpret, and present experimental results at lab meetings and share scientific results with our multi-disciplinary research group.Publish/present findings in peer-reviewed journals/scientific conferences.Work well with colleagues in a matrixed, fast-paced pharmaceutical research environment.Maintain accurate records of experiments and analyses.Maintain lucid and effective communication with manager and other colleagues Basic Qualifications: PhD in Immunology or Immuno-Oncology with publications in internationally recognized journals in the area of NK cell biology. Expertise in NK cell biology, characterization and functional manipulation.Experience in cell culture, cell-based assays, co-culture systems, multicolor flow cytometry and FACSExcellent English speaking, reading and writing skillsStrong analytical and organizational skillsCuriosity and a willingness to work independently and in collaboration with internal and external partners.Excellent teamwork skills and flexibility Preferred Qualifications: Expertise in NK cell functional screens implementation and analysis.Expertise in gene editing and/or gene expression will be appreciated.A first experience as a post-doc in Immuno-Oncology and/or NK cell biology is a plus (0-2 years of prior postdoctoral training). Basic French speaking skills are preferred but not mandatory